A-148 The Association of Neighborhood Trust and Violence with White Matter Integrity in a Diverse Sample

Abstract Objective: Hispanic and non-Hispanic Black older adults are at increased risk of dementia compared with Whites. Cerebral white matter disease may contribute to this disparity, though little is known about how factors such as neighborhood disadvantage perceived economic status relate integrity in diverse groups. Method: Participants from a population-based, multiethnic cohort (N=2766; Female=58%; Black=48%; Hispanic=14%) completed measure perceptions (“resources,” “trust,” “violence”) SES (“access food,” “access healthcare”) underwent 3T brain MRI 2D FLAIR 3D T1-weighted sequences assess hyperintensity (WMH) burden volume (WMV), respectively. Linear regression models examined associations among these variables controlling for demographic traditional (income, education), followed by post-hoc analyses race/ethnicity sex. Results: Reported income, education, ethnoracial group, sex were associated WMH the overall sample (ps<.05), healthcare,” race/ethnicity, significantly cerebral WMV. Post-hoc revealed “violence” was more women (p<.05,β=-0.12), lower “trust” WMV men (p<.05,β=0.22), medical care” White (p<.05,β=-0.18). Conclusions: Neighborhood indicators pathology, differential relationships across race Findings reflect disproportionate environmental social stressors encountered some Future will examine whether sociocultural cognitive function later life.